产品详情
  • 名称:离体心脏灌注系统

  • 型号:IH-SR
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简单介绍:
*IH-SR 适用于小型啮齿动物的离体心脏灌注系统(小鼠、大鼠和豚鼠)
详情介绍:

灌注系统概述

HSEHA生理学系统是一系列应用广泛的完备产品,可用于整体动物生理学、立体或在体器官和组织灌注及组织浴槽研究。这些系统具有广泛的应用,包括传统的安全药理学、DMPK、毒理学、呼吸系统、心脏病学、分子生物学和生理学。每个系统都设计了标准的组件,再加一些其他配置以适合特殊研究的需要。。标注组件也意味着如果你是需要将现有设备配齐,或者进行系统升级,或者是完整的配套产品,你都只需要购买需要的构件。HSE-HA生理学系统为你提供各种工具,使你的研究走向多产和成功。

我们提供大多数生理学检测设备,包括放大器、电极、传感器和电化学检测器。参数包括力、位移、压力、液体和气体流、心电图(单导联—12导联系统)、MAP(单个或多个部位)、脑电图、肌电图、连续支流灌注传统的血气参数和电解质的分析,可以选择程序化软件和传统的刺激器作为放大器、电极和传感器等产品的补充。

HSE-DAQ系统产品家族(BDASACADHAEMODYNISOHEARTPULMODYNPENNOCK)可以记录你的初始信号,计算到处的参数,注释数据,快速简易的输入确定的数据用于分析。同时还可以选择用于进一步分析的软件模块,带状记录纸打印,自动和控制模块等。产品经过预先设置,打开包装即可使用,并专门设计符合你的系统配置和数据分析要求。

 

• Constant pressure or constant flow perfusion of isolated rodent hearts with the same apparatus

• Compact unit improved for low volume and high temperature stability

• High perfusion pressure possible (up to 300 mmHg)

• Continuous measurement of heart mechanics and bioelectrical signals

• Langendorff or Working Heart Configurations – Easy to Upgrade

• The special flow resistance and compliance chamber closely mimics the in-vivo afterload

• Applications:

– Testing inotropic and vasoactive substances

– Testing cardiac rhythm (chronotropic and arrythmogenic effects)

– Assessment of the refractory period

– Cardiovascular screening of transgenic mice

 

The IH-SR apparatus has been designed for experiments on the isolated heart of small rodents like rats or guinea pigs, and especially mice. Available in two versions: LH = Langendorff Heart and WH = Working Heart. Both versions allow easy conversion between constant pressure and constant flow conditions. The WH version of the apparatus allows isolated heart experiments in both LH or WH mode. Mode changeover is performed through a few simple manipulations; no additional conversion of the apparatus required. The precision design simplifies system use and minimizes user error.

In LH mode, the coronary vessels are perfused by retrograde flow through the aorta. Under constant pressure conditions, coronary flow can be measured with a flow probe while in constant flow experiments, the perfusion pressure can be measured with a pressure transducer. Measurement of isovolumetirc left ventricular pressure (LVP) (balloon method) is facilitated by custom LVP balloon catheters.

In WH mode the left atrium is cannulated and the heart performs pressure-volume work. Atrial preload is set by a simple fluid column height adjustment. Measurable parameters in WH mode include perfusion pressure, aortic flow, total cardiac output from left atrial flow, atrial preload pressure, LVP pressure via aortic cannulation or ventricular cannulation.

Parameters that can be monitored in either LH or WH modes include ECG, and Monophasic Action Potential. Traditional blood gas measurements (pO2, pCO2 and pH) as well as ion concentrations can also be monitored by pulmonary artery cannulation in rats and guinea pigs but is not available for mice.

• Constant pressure or constant flow perfusion of isolated rodent hearts with the same apparatus

• Compact unit improved for low volume and high temperature stability

• High perfusion pressure possible (up to 300 mmHg)

• Continuous measurement of heart mechanics and bioelectrical signals

• Langendorff or Working Heart Configurations – Easy to Upgrade

• The special flow resistance and compliance chamber closely mimics the in-vivo afterload

• Applications:

– Testing inotropic and vasoactive substances

– Testing cardiac rhythm (chronotropic and arrythmogenic effects)

– Assessment of the refractory period

– Cardiovascular screening of transgenic mice

 

 

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