产品详情
  • 名称:离体肺灌注系统

  • 型号:IL-1
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简单介绍:
IL-1 适用于小鼠的离体肺灌注系统
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灌注系统概述

HSEHA生理学系统是一系列应用广泛的完备产品,可用于整体动物生理学、立体或在体器官和组织灌注及组织浴槽研究。这些系统具有广泛的应用,包括传统的安全药理学、DMPK、毒理学、呼吸系统、心脏病学、分子生物学和生理学。每个系统都设计了标准的组件,再加一些其他配置以适合特殊研究的需要。。标注组件也意味着如果你是需要将现有设备配齐,或者进行系统升级,或者是完整的配套产品,你都只需要购买需要的构件。HSE-HA生理学系统为你提供各种工具,使你的研究走向多产和成功。

我们提供大多数生理学检测设备,包括放大器、电极、传感器和电化学检测器。参数包括力、位移、压力、液体和气体流、心电图(单导联—12导联系统)、MAP(单个或多个部位)、脑电图、肌电图、连续支流灌注传统的血气参数和电解质的分析,可以选择程序化软件和传统的刺激器作为放大器、电极和传感器等产品的补充。

HSE-DAQ系统产品家族(BDASACADHAEMODYNISOHEARTPULMODYNPENNOCK)可以记录你的初始信号,计算到处的参数,注释数据,快速简易的输入确定的数据用于分析。同时还可以选择用于进一步分析的软件模块,带状记录纸打印,自动和控制模块等。产品经过预先设置,打开包装即可使用,并专门设计符合你的系统配置和数据分析要求。

 

• Investigation of ventilation and perfusion in the isolated mouse lung

• Non-damaging in-situ preparation

• Negative-pressure ventilation similar to in-vivo condition

• Regular induction of deep inspiration (sigh, augmented breath)

• Pneumotachometer and air humidifier with small dead volume

• Continuous measurement of respiratory mechanics (tidal volume, airway resistance, dynamic compliance) and perfusate characteristics (pressure, lung vascular resistance, pO2, pH)

 

Most of the studies with isolated perfused lungs have been performed with lungs obtained from rats, guinea pigs, rabbits or dogs. The interaction of the immune system with the lung is currently an area of great interest. The mouse is the best characterized rodent species with respect to its immune system. Immunologic probes such as antibodies and cytokines are more widely available for mice versus other species. To facilitate studies on the interaction of the lung and the immune system, an apparatus for perfusing and ventilating mouse lungs has been developed. This apparatus is also suitable for studying the respiratory system of knock-out mice.

Ventilation

The lung is placed in the artificial thoracic chamber and ventilated at negative pressure. It is connected through the tracheal cannula to the pneumotachometer for measurement of respiratory flow. The respiration rate, the inspiratory and the end-expiratory pressure can be adjusted by separate controls (Positive ventilation using a regular Minivent ventilator is also possible).

Perfusion

The pulmonary artery is cannulated to provide perfusion. The perfusate is passed by means of a roller pump at constant flow through the heat exchanger, through a bubble trap to the pulmonary artery and finally into the lung vascular bed. The perfusate outflow is usually provided by cannulating the left atrium of the heart.

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