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  • 名称：无创血压仪

  • 型号：MK-2000ST
  • 厂商：Muromachi
  • 文档：
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简单介绍：
全球开创非侵入性、非预热加温的大小鼠无创血压仪，不同于传统的大小鼠无创血压仪，在室温23℃以上就可以自然地量测老鼠的子血压，很适合用来调查**对动物的影响，一旦动物在Holder内有安置好，则只要按下开始键，则HR ，SBP ，MBP，DBP就可以自动测量到。自然基因科技拥有经过厂家培训的专业技术人员，为您提供专业又贴心的技术服务。无创血压仪
详情介绍：
Muromachi MK-2000ST 
不需预热、非侵入式无创大小鼠血压仪

 
全球开创非侵入性、非预热加温的大小鼠无创血压仪，不同于传统的大小鼠无创血压仪，在室温23℃以上就可以自然地量测老鼠的子血压，很适合用来调查**对动物的影响，一旦动物在Holder内有安置好，则只要按下 START键，则HR (Heart Rate), SBP (Systolic BP), MBP (Mean BP) and DBP (Diastolic BP, calculated value)就可以自动测量到。


特色:

1. 一般很难量到血压的colored mice (如 C57 BL/6)，仓鼠(麻醉)及天竺鼠(无麻醉)，使用
    Muromachi MK-2000ST都可以测得到其血压。

2. 初生鼠(小到 1.4g)~成鼠(1kg)都可以测到其血压。

3. 测量老鼠尾部血压不需再加热，室温23°C以上即可。

4. 操作简单，可设定手动或自动连续测量。

5. 测量时显示脉波图，测量结果数字显示：收缩压、平均血压、舒张压及心跳。

6. 内建快速打印机，可即时打印结果，并可用串口将数据传至电脑。

tail-cuff method without heating,

(尾部测量) (MK-2000ST)

Conventional heating tail-cuff method,

(unanesthetized rats with heating) (尾部测量)

特色：

l 当周边环境温度高于23 °C 时，不需要将实验动物加热

l 目前市面上，**可同时量mice & rat的仪器

l 方法简单，设备不昂贵

 

　

 

特色：

l  需要将老鼠加热

l  方法简单，设备不昂贵

 缺点：

l 加热的过程或限制动物移动的行为，可能会对老鼠造成压迫(stress-induced)，使得其血压受到影响，并可能伤害老鼠的健康

 

 

Telemetry method,

(unanesthetized restrained rats without heating) (遥测技术)

Carotid arterial catheter method,

(anesthetized rats, carotid arterial cannulation) (动脉导管技术)

特色：

l 适用于心血管**鼠的量测，因为不会对老鼠产生压迫，造成血压改变

l 对于心血管的研究相当有用

l 不限制老鼠活动范围

 缺点：

l 要将无线发送器植入老鼠腹部，而仪器也相当昂贵

特色：

l 可直接量测到BP & HR


缺点：

l 麻醉开腔插管手术可能会导致老鼠血压、心跳、体温降低

 

 



主要特性：

1.  无创血压仪两种操作模式：
     模式1 HR(心率)，模式2 SBP（收缩压）
     模式2中可以测量 HR/SBP/MBP(平均血压)/DBP（舒张压，计算值）
     
MODE1 HR SBP
MODE2 HR SBP MBP (DBP)
 

注意：HR (Heart Rate), SBP (Systolic BP), MBP (Mean BP),
         DBP (Diastolic BP, calculated value)

2.  无创血压仪连续测量功能：
     连续测量可以*大到10次，此外为了得到更短的测量时间，也可以连续快速测量

3.  无创血压仪快速打印功能：
     屏幕上的数据包括平均值（AV）和标准差（SD），1秒钟即可打印输出 

4.  患病动物也可测量（例如心肌梗塞的动物）

5.  无需多通道系统，只需要准备多重抑制剂，既可以很快测量

6.  一般很难量到血压的有色老鼠colored mice (如 C57 BL/6)，仓鼠(麻醉)及
     天竺鼠(无麻醉)，使用 Muromachi MK-2000ST都可以测得到其血压。 

7.  无创血压仪自动序列功能：
      动物的尾动脉血压能够自动监测，时间间隔可以是1-99分钟。每一次间隔，能够
      检测1-10次。该全自动功能可以被输出打印。 

8.  时间印记功能：
     MK-2000ST**记录每一次BP测量的时间

9.  硬拷贝功能：
    屏幕上显示的一切都可以被拷屏打印，只需要摁一下PRTSCREEN按键

10. 串口连接：
      DCS-2000数据采集软件

11. 动物管是由黑色棕丙烯醛基制作，动物在相当安静无干扰的环境下测量

12.  操作简单


室町科技的大小鼠无创血压仪是目前世界上*好的大小鼠无创血压仪设备，分为两种不同类型的大小鼠无创血压仪，一种是无需预热的大小鼠无创血压仪，另外一种是便携性经济型的大小鼠无创血压仪。




Correlation between simultaneously recorded blood pressures (BP) from carotid catheter and BP measured with the Model MK-2000 in mice. Good correlation was seen in a wide range of BP, which was induced by i.v. infusions of pressor or depressor agents.

SPECIFICATIONS

Main Unit  (MK-2000ST)
SBP Cuff pressure when pulse reappears
MBP Cuff pressure when pulse amplitude becomes largest
DBP Calculated value based on SBP and MBP   (3MBP-SBP)/2
Detection LED,  Photo Transistor
Inflation Range 0 - 350mmHg
Printer Outputs Date, Time, Animal No., Weight, Operation Mode, Interval,   No of Measuring Trials, Raw Data,  Average and S.D.
Chart Paper

Thermo-sensitive 58 mm Wide x 25m Long
Power AC100-130V 50/60Hz
Dimensions 210W x 310D x 210 mmH
Weight Approx.  8 kg

 

 Keyboard
Function Keys 33
Dimensions 145W x120D x20 mmH
Weight Approx.  0.4 kg

　

The Standard System Comes Supplied with:
Main Unit (Printer included) 1
Keyboard 1
Animal Holder (Any one from the list) 1
Cuff-pulse Sensor (Any one from the list) 1
Measuring Stand for Rats 1
TSP-10 Chart Paper (Pack of 5 Rolls) 1
APC-2000 Accessory Case 1
Dust Cover 1

　

 
 
 
 
Animal Holders
Mouse Holder (3S) 5-10g
Mouse Holder (SS) 10-20g
Mouse Holder (S) 20-30g
Mouse Holder (M) 30-40g
Mouse Holder (L) 40-50g
Rat Holder (3S) 50-70g
Rat Holder (SS) 70-90g
Rat Holder (S) 90-150g
Rat Holder (SM) 150-210g
Rat Holder (M) 210-270g
Rat Holder (ML) 270-350g
Rat Holder (L) 350-500g
Rat Holder (LL) 500-800g
Cuff-Pulse Sensors
Neo24NH 1.4 - 2g
Neo32NH 2 - 5g
Neo40NH 5 - 10g
Mouse NH 20-50g
OB Mouse NH OB Mouse & Mouse 5 - 20g
C57 Mouse NH C57BL6 Mouse
Hamster (S)NH Approx.  60-80g
Hamster (M)NH Approx.  80-120g
Hamster (L)NH Approx 120-160g
Rat (S)NH 90-210g
Rat (M)NH 210-350g
Rat (ML)NH 350-500g
Rat (L)NH 500-800g




利用本无创血压仪仪器发表的参考文献：

  1. Design and production of genetically modified soybean protein with anti-hypertensive activity by incorporating potent analogue of ovokinin (2-7) (FEBS Letters 24860 (2001) 1-5
    Nobuyuki Matoba, Naomi Doyama, Yuko Yamada, Nobuyuki Maruyama, Shigeru Utsumi,  Masaaki Yoshikawa
    Research Institute For Food Science,  Kyoto University,  Uji  Kyoto 611-0011, Japan
    Animal used : SHR

  2. Design of a Highly Potent Anti-hypertensive Peptide Based on Ovokinin(2-7) (Biosci. Biotechnol. Biochem.,66(6), 1213-1217,2002)
    Yuko Yamada, Nobuyuki Matoba, Hachiro Usui, Kunihiko Onishi, and Masaaki Yoshikawa
    Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan
    Animal used : SHR and Wky Rat

  3. Syndecan-4 Deficiency Leads to High Mortality of Lipopolysaccharide-injected Mice (The Journal of Biological Chemistry, Vol. 276, No. 50, Issue of December 14, pp. 47483-47488, 2001)
    Kazuhiro Ishiguroö˜,  Kenji Kadomatsuö÷,  Tetsuhito Kojimaö÷||,  Hisako Muramatsuö,  Mitsunori Iwase||,
    Yasunobu Yoshikai**,  Masamitsu Yanadaö˜,  Koji Yamamoto˜, Tadashi  Matsushita˜,  Masahiko Nishimuraöö
    Kazuo Kusugami˜,  Hidehiko Saito˜ ˜˜,  and Takashi Muramatsuö÷÷
    From the öDepartment of Biochemistry, ˜First Department of Internal Medicine, **Laboratory of Host Defense & Germfree Life, Research Institute for Disease Mechanism and Control, and ööInstitute for Laboratory Animal Research, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan, the ||Department of  Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673,Japan, and the ˜˜Nagoya National Hospital, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan

  4. Validity and Application of Noninvasive Measurement of Blood Pressure in Hamsters (Exp.Anim. 52(4), 359-363, 2003)
    Kato Y,  Iwase M,  Kanazawa H,  Nishizawa T,  Zhao YL,  Takagi K,  Nagata K,  Noda A,  Koike Y,  Yokota M
    School of Health Sciences, Nagoya University, 1-1-20 Daiko-minami, Higashi-ku, Nagoya 461-8673, Japan.

  5. Progressive Development of Pulmonary Hypertension Leading to Right Ventricular Hypertrophy Assessed by Echocardiography in Rats (Exp. Anim. 52(4), 285-294, 2003)
    Yosuke KATO1), Mitsunori  IWASE1), Hiroaki  KANAZAWA1),  Natsuki  KAWATA1) ,Yukie YOSHIMORI,1)
    Katsunori HASHIMOTO1),  Toyoharu YOKOI1),  Akiko NODA1),  Kenzo TAKAGI1),  Yasuo KOIKE1),
    Takao NISHIZAWA2),  Masahiko NISHIMURA2), and Mitsuhiro YOKOTA2)
    1)School of Health Science, Nagoya University,1-1-20 Daiko-minami,Higashi-ku, Nagoya 461-8673, and,
    2)Graduate School of Medicine, NagoyaUniversity,65 Tsurumai-cho, Showa-ku,Nagoya 466-8550,Japan

  6. Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth (The Journal of Clinical Investigation July 2003 Vol.112, No. 1)
    Kimiyasu Egami,1,2 Toyoaki Murohara,1,3,4 Toshifumi Shimada,1,3 Ken-ichiro Sasaki,1,3
    Satoshi Shintani,1,3 Takeshi Sugaya,5 Masahiro Ishii,1,2 Teiji Akagi,1,2 Hisao Ikeda,1,3
    Toyojiro Matsuishi,1,2 and Tsutomu Imaizumi1,3
    1 The Cardiovascular Research Institute,
    2 Department of Pediatrics, and
    3 Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    4 Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    5 Discovery Research Laboratory, Tanabe Seiyaku Co., Osaka, Japan
    Animal used : C57BL6 Mouse

  7. Growth hormone-releasing peptide can improve left ventricular dysfunction and attenuate dilation in dilated cardiomyopathic hamsters  (Cardiovascular Research 61 (2004) 30-38)
    Iwase, M., Kanazawa, H., Kato, Y., Nishizawa, T., Somura, F., Ishiki, R., Hagata, K., Hashimoto, K., Takagi, K., Izawa, H. and Yokota,

  8. Development of an in vivo Bioassay Method for Allergy-Preventive Substances using HEL-induced Blood Flow Decrease (Biol. Pharm. Bull)
    Kyoko Ishiguro1), Hisae Oku1), Yoshimi Ueda1), Emiko Iwaoka1) and Masaru Kunitomo1)
    1) School of Pharmaceutical Sciences, Mukogawa Women's University
    Animal used : ddY Mouse

  9. Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle (NATURE MEDICINE Volume 10 Number 11  November 2004)
    Takahiro Iwamoto1,3, Satomi Kita1,5, Jin Zhang2, Mordecai P Blaustein2, Yuji Arai4, Shigeru Yoshida5,
    Koji wakimoto6, Issei Komuro7&Takeshi Katsuragi1
    1 Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
    2 Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
    3 Department of Molecular Physiology, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan.
    4 Department of Bioscience, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan.
    5 Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama 330-8530, Japan.
    6 Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka 532-8505, Japan.
    7 Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
    Animal used : C57BL6 Mouse

  10. The vascular relaxing effects of sevoflurane and isoflurane are more important in hypertensive than in normotensive rats (Canadian Journal of Anesthesia 51: 979-985, 2004)
    Jingui Yu, MD*, Koji Ogawa, MD, Yasuyuki Tokinaga, MD*, Shizue Iwahashi, MD* and Yoshio Hatano, MD*
    * From the Department of Anesthesiology, and the Surgical Operating Center, Wakayama Medical University, Wakayama City, Japan.

  11. Angiogenesis and Vasculogenesis Are Impaired in the Precocious-Aging klotho Mouse(American Heart Association  Circulation. 2004;110:1148-1155.)
    Toshifumi Shimada, MD; Yoshiaki Takeshita, MD; Toyoaki Murohara, MD; Ken-ichiro Sasaki, MD;
    Kimiyasu Egami, MD; Satoshi Shintani, MD; Yosuke Katsuda, MD; Hisao Ikeda, MD;
    Yo-ichi Nabeshima, MD; Tsutomu Imaizumi, MD
    From the Cardiovascular Research Institute (T.S., Y.T., T.M., K.-i.S., K.E., S.S., Y.K., H.I., T.I.), Kurume University, Kurume; the Department of Cardiology (T.M.), Nagoya University Graduate School of Medicine, Nagoya; and the Department of Pathology and Tumor Biology (Y.-i.N.), Kyoto University Graduate School of Medicine, Kyoto, Japan.

  12. Effects of Captoprill on Cardiac and Renal Damage, and Metabolic Alterations in the Nitric Oxide-Deficient Hypertensive Rat (Kidney Blood Pressure Research 2005; 28: 243-250)
    Mahmoud M. Khattab Adel Mostafa Othman Al-Shabanah
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh , Saudi Arabia

  13. Rat Phenome Project: The untapped potential of existing rat strains  (J Appl Physiol 98: 371-379, 2005)
    Tomoji Mashimo, Birger Voigt, Takashi Kuramoto, and Tadao Serikawa
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan

  14. An X-Ray Diffraction Study on Mouse Cardiac Cross-Bridge Function In Vivo: Effects of Adrenergic ß-Stimulation (Biophysical Journal 90:1723-1728 (2006)
    Ryuji Toh,* Masakazu Shinohara,* Tomofumi Takaya,* Tomoya Yamashita,* Shigeru Masuda,*
    Seinosuke Kawashima,* Mitsuhiro Yokoyama,* and Naoto Yagiy
    *Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine,Kobe 650-0017, Japan; and ySPring-8/JASRI, Sayo, Hyogo 679-5198, Japan

  15. Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice (Am J Physiol Lung Cell Mol Physiol 290: L59-L65, 2006.)
    Shinsuke Murakami,1,2 Noritoshi Nagaya,1,3 Takefumi Itoh,2 Masaharu Kataoka,1 Takashi Iwase,1
    Takeshi Horio,3 Yoshinori Miyahara,4 Yoshiki Sakai,5 Kenji Kangawa,6 and Hiroshi Kimura2
    1Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research
    Institute, Osaka; 2Second Department of Internal Medicine, Nara Medical University, Nara; 3Department of
    Internal Medicine, National Cardiovascular Center, Osaka; 4Department of Cardiac Physiology, National
    Cardiovascular Center Research Institute, Osaka; 5Ono Pharmaceutical Co., Ltd. Research Headquarters,
    Osaka; and 6Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan

  16. Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide Obtained from Hen Ovotransferrin (Journal of the Chinese Chemical Society, 2006, 53, 495-501)
    Nai-Yuan Leea, Juei-Tang Chengb, Toshiki Enomotoc, Ichiro Nakamurad,
    a Livestock Research Institute, Tainan 712, Taiwan, R.O.C.
    b Department Pharmacology, College of Medicine, National Cheng Kung University,
       Tainan 70101, Taiwan, R.O.C.
    c Department of Food Science, Ishikawa Prefectural University, Nonoichi, Ishikawa 9218836, Japan
    d Institute of Animal Experimentation, School of Medicine, Hokkaido University, Sapporo 0608589, Japan
    Animal used : SHR

  17. Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats (Biol. Pharm. Bull. 29(8) 1756-1758 (2006) Vol. 29, No. 8
    KUBOTA Yoko1 UMEGAKI Keizo2 KAGOTA Satomi 3 TANAKA Naoko 4 NAKAMURA Kazuki 5 KUNITOMO Masaru 6 SHINOZUKA Kazumasa 7
    1 Department of Biopharmaceutics, Nihon Pharmaceutical University
    2 National Institute of Health and Nutrition
    3 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    4 Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
    5 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    6 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    7 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University

  18. Mechanical ventilation with 40% oxygen reduces pulmonary expressionof genes that regulate lung development and impairs alveolar septation in newborn mice
    (Am J Physiol Lung Cell Mol Physiol 293:1099-1110, 2007. )
    Richard D. Bland, Lucia M. Mokres, Robert Ertsey, Berit E. Jacobson, Shu Jiang, Marlene Rabinovitch,
    Liwen Xu, Eric S. Shinwell, Feijie Zhang, and Matthew A. Beasley
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California

19.  Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of  
       newborn mice.
      (Am J Physiol Lung Cell Mol Physiol 294:L3-L14, 2008. )
     Richard D. Bland, Robert Ertsey, Lucia M. Mokres, Liwen Xu, Berit E. Jacobson, Shu Jiang,
     Cristina M. Alvira, Marlene Rabinovitch, Eric S. Shinwell, and Anjali Dixit
        Department of Pediatrics, Stanford University School of Medicine, Stanford, California


无创血压仪联系电话：010-51650520


 

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我们的标准服务流程为：
 
l 仪器完好无损运送到客户处
l 专业工程师接到派工单，与客户主动联系：了解客户现场情况、告知客户需要准备的必要条件、与客户约定安装培训时间
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l 在客户指定的符合仪器运行条件的位置，安装仪器
l 测试电压并开机试运行仪器
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l 向客户介绍仪器的硬件操作
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l 2-4周后回访客户，并解答客户提出的在使用中出现的问题
 
 
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