产品详情
  • 名称:离体心脏灌注系统

  • 型号:IH-9
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简单介绍:
IH-9 使用于小猪的离体心脏灌注系统
详情介绍:

灌注系统概述

HSEHA生理学系统是一系列应用广泛的完备产品,可用于整体动物生理学、立体或在体器官和组织灌注及组织浴槽研究。这些系统具有广泛的应用,包括传统的安全药理学、DMPK、毒理学、呼吸系统、心脏病学、分子生物学和生理学。每个系统都设计了标准的组件,再加一些其他配置以适合特殊研究的需要。。标注组件也意味着如果你是需要将现有设备配齐,或者进行系统升级,或者是完整的配套产品,你都只需要购买需要的构件。HSE-HA生理学系统为你提供各种工具,使你的研究走向多产和成功。

我们提供大多数生理学检测设备,包括放大器、电极、传感器和电化学检测器。参数包括力、位移、压力、液体和气体流、心电图(单导联—12导联系统)、MAP(单个或多个部位)、脑电图、肌电图、连续支流灌注传统的血气参数和电解质的分析,可以选择程序化软件和传统的刺激器作为放大器、电极和传感器等产品的补充。

HSE-DAQ系统产品家族(BDASACADHAEMODYNISOHEARTPULMODYNPENNOCK)可以记录你的初始信号,计算到处的参数,注释数据,快速简易的输入确定的数据用于分析。同时还可以选择用于进一步分析的软件模块,带状记录纸打印,自动和控制模块等。产品经过预先设置,打开包装即可使用,并专门设计符合你的系统配置和数据分析要求。

 

The Isolated Heart Size 9 has been developed to perform experiments with hearts from small pigs with a body weight up to about 10 kg (heart weight 40 g). The system can be operated in any one of the three methods (Constant Pressure CP, Constant Flow CF, Working Heart WH). The perfusion flow is limited to 500 ml/min for retrograde perfusion and the aortic flow to 1.5 l/min for a working heart system. The system allows standard haemodynamic as well as ischemia-reperfusion studies using saline or erythrocytes containing perfusion solutions. The complete apparatus is mounted on a trolley. It consists of the jacketed heart chamber, its cover with the connections to the heart, pumps, thermostatic circulator and measuring system.

Special Version:

For heart transplantation and cardioplegia studies, the apparatus is equipped with a special option. With this option the heart can be perfused from a second perfusion circuit in retrograde mode using a different perfusion solution (e.g., perfluorocarbon emulsion). Cardioplegia solutions can be injected or infused through a dedicated port.

 

• Isolated perfused small pig heart (heart weight up to 40 g) in retrograde perfusion

• Working heart mode, the special flow resistance and compliance chamber mimics closely the in-vivo afterload

• Compact, easy to use

• Special version for cardioplegia studies in heart transplant studies

• Applications: - Studies of recovery in heart transplantation

- Studies of cardioplegia techniques and solutions

- Evaluation of pacemaker

 

The main part of the apparatus is the cover of the heart chamber. The aortic block is mounted on this cover. In the working heart version the preload reservoir is mounted on the cover and consequently located into the heart chamber. The large heart chamber serves as perfusate reservoir. The chamber can be moved down during the preparation with a lift-system. The way of functioning is identical to the isolated heart system size 5, see page K4.

Saline perfusion solutions are oxygenated by bubbling in the chamber using a frit. If erythrocytes-containing perfusates are used, a membrane oxygenator as used in the heart-lung machine is necessary.

The measured signals as well as the computed parameters in the different modes are the same for the Isolated Heart Setup Size 9 as for the setup IH-SR 5. The size of the flowprobes must be adapted to the corresponding diameters.

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